Searchable abstracts of presentations at key conferences in endocrinology

ea0005p127 | Endocrine Tumours and Neoplasia | BES2003

Proliferative regulation of human breast cancer cells by dietary phytoestrogens: Mechanisms of estrogen receptor-mediated signalling

Limer J , Speirs V

Epidemiological data suggests a correlation between phytoestrogen consumption and a reduced incidence of breast cancer. Current in vitro data is ambiguous, suggesting differential proliferative effects of phytoestrogens depending on ER expression status and exogenous estradiol levels. This study aims to characterise the growth inhibitory effects of the isoflavones genistein and daidzein using a panel of human breast cancer cell lines.Flow cytometry revealed low leve...